Low-glycemic-index treatment: A liberalized ketogenic diet for treatment of intractable epilepsy

被引:213
作者
Pfeifer, HH
Thiele, EA
机构
[1] Massachusetts Gen Hosp, Pediat Epilepsy Serv, Pediat Epilepsy Program, Dept Neurol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
关键词
D O I
10.1212/01.wnl.0000187071.24292.9e
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The ketogenic diet is often effective for intractable epilepsy, but many patients have trouble complying with the strict regimen. The authors tested an alternative diet regimen, a low-glycemic-index treatment, with more liberal total carbohydrate intake but restricted to foods that produce relatively little increase in blood glucose (glycemic index < 50). Ten of 20 patients treated with this regimen experienced a greater than 90% reduction in seizure frequency.
引用
收藏
页码:1810 / 1812
页数:3
相关论文
共 10 条
[1]   The use of diet in the treatment of epilepsy [J].
Bailey, EE ;
Pfeifer, HH ;
Thiele, EA .
EPILEPSY & BEHAVIOR, 2005, 6 (01) :4-8
[2]   Efficacy and safety of low-carbohydrate diets - A systematic review [J].
Bravata, DM ;
Sanders, L ;
Huang, J ;
Krumholz, HM ;
Olkin, I ;
Gardner, CD ;
Bravata, DM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (14) :1837-1850
[3]   The ketogenic diet upregulates expression of the gene encoding the key ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in rat brain [J].
Cullingford, TE ;
Eagles, DA ;
Sato, H .
EPILEPSY RESEARCH, 2002, 49 (02) :99-107
[4]   Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose [J].
Greene, AE ;
Todorova, MT ;
McGowan, R ;
Seyfried, TN .
EPILEPSIA, 2001, 42 (11) :1371-1378
[5]  
HAYMOND MW, 1983, AM J PHYSIOL, V245, P373
[6]   KETONEMIA AND SEIZURES - METABOLIC AND ANTICONVULSANT EFFECTS OF 2 KETOGENIC DIETS IN CHILDHOOD EPILEPSY [J].
HUTTENLOCHER, PR .
PEDIATRIC RESEARCH, 1976, 10 (05) :536-540
[7]   GLYCEMIC INDEX OF FOODS - A PHYSIOLOGICAL-BASIS FOR CARBOHYDRATE EXCHANGE [J].
JENKINS, DJA ;
WOLEVER, TMS ;
TAYLOR, RH ;
BARKER, H ;
FIELDEN, H ;
BALDWIN, JM ;
BOWLING, AC ;
NEWMAN, HC ;
JENKINS, AL ;
GOFF, DV .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1981, 34 (03) :362-366
[8]   BRAIN METABOLISM DURING FASTING [J].
OWEN, OE ;
MORGAN, AP ;
KEMP, HG ;
SULLIVAN, JM ;
HERRERA, MG ;
CAHILL, GF .
JOURNAL OF CLINICAL INVESTIGATION, 1967, 46 (10) :1589-&
[9]   Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet [J].
Schwartzkroin, PA .
EPILEPSY RESEARCH, 1999, 37 (03) :171-180
[10]   General anesthesia and the ketogenic diet: Clinical experience in nine patients [J].
Valencia, I ;
Pfeifer, H ;
Thiele, EA .
EPILEPSIA, 2002, 43 (05) :525-529