Combination of porphyrins and DNA-alkylation agents: Synthesis and tumor cell apoptosis induction

被引：16

作者：

He, HP

Zhou, Y

Liang, F

Li, DQ

Wu, JJ

Yang, L

Zhou, X ^{[1
]}

Zhang, XL

Cao, XP

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

[2] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China

[3] Wuhan Univ, Zhong Nan Hosp, Wuhan 430071, Peoples R China

[4] Wuhan Univ, Coll Med, Wuhan 430071, Peoples R China

[5] Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 04期

基金：

中国国家自然科学基金;

关键词：

porphyrin; apoptosis; morphological change;

D O I：

10.1016/j.bmc.2005.09.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of porphyrin-DNA cross-linking Conjugates were synthesized. Their cytotoxicities to tumor cells were tested using MTT assays first. Then, HeLa cell apoptosis induced by these cationic porphyrins under the light was examined by laser confocal microscopy, flow cytometric analysis, and further confirmed by observing the morphological changes and DNA fragmentation mainly. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1068 / 1077

页数：10

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