The biology and therapeutic potential of natural regulatory T-cells in the bone marrow transplant setting

被引：20

作者：

Coghill, James M. ^{[1
,2
]}

Carlson, Michael J. ^{[1
,3
]}

Moran, Tim P. ^{[1
,3
]}

Serody, Jonathan S. ^{[1
,2
,3
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Med, Div Hematol Oncol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Med, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

LEUKEMIA & LYMPHOMA | 2008年 / 49卷 / 10期

关键词：

Immunotherapeutic approaches; transplant rejection: responses to alloantigens; T-cell mediated Immunity; graft-versus-host disease;

D O I：

10.1080/10428190802272684

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Graft-versus-host disease (GVHD) remains a major barrier to the long-term success of allogeneic hematopoietic stem-cell transplantation for hematologic malignancies. This has prompted a great deal of interest in the development of alternative GVHD management strategies such as the adoptive transfer of lymphocytes with immunosuppressant activity. This review will focus on the biology of thymically derived regulatory T-cells (Tregs) and their potential therapeutic role in human bone marrow transplantation. A discussion of their basic suppressive mechanisms and invivo trafficking patterns will be presented, along with an overview of important preclinical studies using murine GVHD/tumor models. Currently available clinical data will also be discussed, including the contribution of Tregs to various transplant outcome parameters such as GVHD incidence and malignancy relapse rates.

引用

页码：1860 / 1869

页数：10

共 77 条

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