Caveolae and caveolin in immune cells: distribution and functions

被引：117

作者：

Harris, J

Werling, D

Hope, JC

Taylor, G

Howard, CJ

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Univ Bern, Inst Vet Virol, CH-3012 Bern, Switzerland

[3] AFRC, Inst Anim Hlth, Compton Lab, Newbury RG20 7NN, Berks, England

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 03期

关键词：

D O I：

10.1016/S1471-4906(01)02161-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.

引用

页码：158 / 164

页数：7

共 74 条

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