Synthesis and anticancer activity of dichloroplatinum(II) complexes of podophyllotoxin

被引：41

作者：

Liu, Xuan ^{[1
]}

Zhang, Lin-Lin ^{[1
]}

Xu, Xiao-Hui ^{[1
]}

Hui, Lin ^{[2
,3
]}

Zhang, Jin-Bang ^{[5
]}

Chen, Shi-Wu ^{[1
,4
]}

机构：

[1] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

[2] Lanzhou Mil Command, Gen Hosp, Ctr Med Expt, Lanzhou 730050, Peoples R China

[3] Lanzhou Mil Command, Gen Hosp, Key Lab Stem Cells & Gene Drug Gansu Prov, Lanzhou 730050, Peoples R China

[4] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[5] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 13期

关键词：

Cisplatin; Podophyllotoxin; Microtubules inhibition; DNA cleavage; BIOLOGICAL EVALUATION; DERIVATIVES; CISPLATIN; AGENTS; DRUGS; 5-FU;

D O I：

10.1016/j.bmcl.2013.04.089

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A series of dichloroplatinum(II) complexes of podophyllotoxin (PPT) were prepared, and their cytotoxicity against sensitive (A-549, HeLa, HCT-8, Hep-G2, K562) and resistant (ADM/K562) cell lines were evaluated. Complex cis-[4 alpha-O-(2 '',3 ''-diaminopropanoyl)-podophyllotoxin] dichloride platinum(II) (12) displayed most potent cytotoxicity with IC50 value in the range 0.071-2.98 mu M. Complex 12 induces cell cycle arrest in the G(2)/M phase, and inhibits the formation of microtubules in HeLa cells. Furthermore, this complex exhibits potent DNA cleavage capabilities. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3780 / 3784

页数：5

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