Medicine: Clearing a path for nerve growth

被引:27
作者
Olson, L [1 ]
机构
[1] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden
关键词
D O I
10.1038/416589a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
After spinal-cord injury, severed nerve fibres face a thicket of obstacles as they try to regenerate. Researchers have used a bacterial enzyme to help prune these obstacles in rats.
引用
收藏
页码:589 / 590
页数:2
相关论文
共 12 条
[1]   Chondroitinase ABC promotes functional recovery after spinal cord injury [J].
Bradbury, EJ ;
Moon, LDF ;
Popat, RJ ;
King, VR ;
Bennett, GS ;
Patel, PN ;
Fawcett, JW ;
McMahon, SB .
NATURE, 2002, 416 (6881) :636-640
[2]   Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function [J].
Cheng, H ;
Cao, YH ;
Olson, L .
SCIENCE, 1996, 273 (5274) :510-513
[3]   Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins [J].
Coumans, JV ;
Lin, TTS ;
Dai, HN ;
MacArthur, L ;
McAtee, M ;
Nash, C ;
Bregman, BS .
JOURNAL OF NEUROSCIENCE, 2001, 21 (23) :9334-9344
[4]   Regeneration of adult axons in white matter tracts of the central nervous system [J].
Davies, SJA ;
Fitch, MT ;
Memberg, SP ;
Hall, AK ;
Raisman, G ;
Silver, J .
NATURE, 1997, 390 (6661) :680-683
[5]   Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery [J].
Hofstetter, CP ;
Schwarz, EJ ;
Hess, D ;
Widenfalk, J ;
El Manira, A ;
Prockop, DJ ;
Olson, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :2199-2204
[6]   A spinal thecal sac constriction model supports the theory that induced pressure gradients in the cord cause edema and cyst formation [J].
Josephson, A ;
Greitz, D ;
Klason, T ;
Olson, L ;
Spenger, C .
NEUROSURGERY, 2001, 48 (03) :636-645
[7]   Improving axonal growth and functional recovery after experimental spinal cord injury by neutralizing myelin associated inhibitors [J].
Karim, F ;
Volker, D ;
Schwab, ME .
BRAIN RESEARCH REVIEWS, 2001, 36 (2-3) :204-212
[8]   Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantation [J].
Lemons, ML ;
Howland, DR ;
Anderson, DK .
EXPERIMENTAL NEUROLOGY, 1999, 160 (01) :51-65
[9]   Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells [J].
Li, Y ;
Field, PM ;
Raisman, G .
SCIENCE, 1997, 277 (5334) :2000-2002
[10]   Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC [J].
Moon, LDF ;
Asher, RA ;
Rhodes, KE ;
Fawcett, JW .
NATURE NEUROSCIENCE, 2001, 4 (05) :465-466