Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders

被引：335

作者：

Catassi, Carlo ^{[1
]}

Bai, Julio C. ^{[2
]}

Bonaz, Bruno ^{[3
]}

Bouma, Gerd ^{[4
]}

Calabro, Antonio ^{[5
]}

Carroccio, Antonio ^{[6
,7
]}

Castillejo, Gemma ^{[8
]}

Ciacci, Carolina ^{[9
]}

Cristofori, Fernanda ^{[10
]}

Dolinsek, Jernej ^{[11
]}

Francavilla, Ruggiero ^{[10
]}

Elli, Luca ^{[12
]}

Green, Peter ^{[13
]}

Holtmeier, Wolfgang ^{[14
]}

Koehler, Peter ^{[15
]}

Koletzko, Sibylle ^{[16
]}

Meinhold, Christof ^{[17
]}

Sanders, David ^{[18
,19
]}

Schumann, Michael ^{[20
]}

Schuppan, Detlef ^{[21
,22
,23
,24
]}

Ullrich, Reiner ^{[20
]}

Vecsei, Andreas ^{[25
]}

Volta, Umberto ^{[26
]}

Zevallos, Victor ^{[21
]}

Sapone, Anna ^{[27
]}

Fasano, Alessio ^{[28
]}

机构：

[1] Univ Politecn Marche, Dept Pediat, I-60121 Ancona, Italy

[2] Hosp Gastroenterol Dr Carlos Bonorino Udaondo, Dept Med, RA-1264 Buenos Aires, DF, Argentina

[3] CHU Grenoble, Dept Gastroenterol & Liver Dis, F-38043 Grenoble, France

[4] Vrije Univ Med Ctr, Dept Gastroenterol & Hepatol, NL-1081 HV Amsterdam, Netherlands

[5] Univ Florence, Dept Expt & Clin Biomed Sci, Gastroenterol Unit, I-50134 Florence, Italy

[6] Giovanni Paolo II Hosp, Dept Internal Med, Sciacca, AG, Italy

[7] Univ Palermo, I-92019 Sciacca, Italy

[8] Univ Rovira & Virgili, Hosp Univ St Joan de Reus, Pediat Gastroenterol Unit, Tarragona 43204, Spain

[9] Univ Salerno, Dept Med & Surg, I-84081 Salerno, Italy

[10] Univ Bari, Interdisciplinary Dept Med, I-70124 Bari, Italy

[11] Univ Med Ctr Maribor, Dept Pediat, Gastroenterol Unit, Maribor 2000, Slovenia

[12] Ctr Prevenz & Diagnosi Malattia Celiaca Fdn IRCCS, I-20122 Milan, Italy

[13] Columbia Univ Med Ctr, Dept Med, Celiac Dis Ctr, New York, NY 10032 USA

[14] Hosp Porz Rhein, Div Gastroenterol & Internal Med, D-51149 Cologne, Germany

[15] Leibniz Inst, German Res Ctr Food Chem, D-85354 Freising Weihenstephan, Germany

[16] Univ Munich Med Ctr, Dr von Hauner Childrens Hosp, Div Pediat Gastroenterol & Hepatol, D-80337 Munich, Germany

[17] Practice Nutr Therapy Meinhold & Team, D-50674 Cologne, Germany

[18] Royal Hallamshire Hosp, Dept Gastroenterol & Hepatol, Sheffield S10 2JF, S Yorkshire, England

[19] Univ Sheffield Med Sch, Sheffield S10 2JF, S Yorkshire, England

[20] Charite, Dept Gastroenterol Rheumatol & Infectiol, D-10203 Berlin, Germany

[21] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, D-55131 Mainz, Germany

[22] Beth Israel Deaconess Med Ctr, Div Gastroenterol, Boston, MA 02215 USA

[23] Beth Israel Deaconess Med Ctr, Celiac Ctr, Boston, MA 02215 USA

[24] Harvard Univ, Sch Med, Boston, MA 02215 USA

[25] St Anna Childrens Hosp, A-1090 Vienna, Austria

[26] Univ Bologna, Dept Med & Surg Sci, I-40138 Bologna, Italy

[27] Univ Naples 2, Dept Gastroenterol, I-80136 Naples, Italy

[28] MassGen Hosp Children, Boston, MA 02129 USA

来源：

NUTRIENTS | 2013年 / 5卷 / 10期

关键词：

gluten sensitivity; celiac disease; wheat allergy; gluten-related disorders; gluten-free diet; FREE DIET; CONTROLLED-TRIAL; DISEASE; CHILDREN; AUTISM; BLIND; WHEAT; PREVALENCE; CHALLENGE; SYMPTOMS;

D O I：

10.3390/nu5103839

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Non Celiac Gluten sensitivity (NCGS) was originally described in the 1980s and recently a re-discovered disorder characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected with either celiac disease (CD) or wheat allergy (WA). Although NCGS frequency is still unclear, epidemiological data have been generated that can help establishing the magnitude of the problem. Clinical studies further defined the identity of NCGS and its implications in human disease. An overlap between the irritable bowel syndrome (IBS) and NCGS has been detected, requiring even more stringent diagnostic criteria. Several studies suggested a relationship between NCGS and neuropsychiatric disorders, particularly autism and schizophrenia. The first case reports of NCGS in children have been described. Lack of biomarkers is still a major limitation of clinical studies, making it difficult to differentiate NCGS from other gluten related disorders. Recent studies raised the possibility that, beside gluten, wheat amylase-trypsin inhibitors and low-fermentable, poorly-absorbed, short-chain carbohydrates can contribute to symptoms (at least those related to IBS) experienced by NCGS patients. In this paper we report the major advances and current trends on NCGS.

引用

页码：3839 / 3853

页数：15

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