Effect of choline ester analogues, noradrenaline and nifedipine on normal and hypertrophied human urinary bladder detrusor muscle

被引:13
作者
King, JA
Huddart, H
Staff, WG
机构
[1] UNIV LANCASTER,INST ENVIRONM & BIOL SCI,DIV BIOL SCI,LANCASTER LA1 4YQ,ENGLAND
[2] ROYAL LANCASTER INFIRM,DEPT UROL,LANCASTER,ENGLAND
来源
GENERAL PHARMACOLOGY | 1998年 / 30卷 / 01期
关键词
acetylcholine; bethanechol; carbachol; detrusor hypertrophy; K-induced contractures; nifedipine; noradrenaline; propionylcholine;
D O I
10.1016/S0306-3623(97)00032-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. Acetylcholine, bethanechol, carbachol and propionylcholine were all agonists of normal human detrusor smooth muscle. The order of potency was found to be carbachol>acetylcholine>bethanachol>propionylcholine. 2. In hypertrophied detrusor smooth muscle carbachol was more potent than acetylcholine, but hypertrophied detrusor preparations were less sensitive to carbachol than normal detrusor smooth muscle. 3. Noradrenaline had no direct effect on either normal or hypertrophied detrusor muscle, but it had a reversible inhibitory effect on the spontaneous contractile activity of normal detrusor preparations. Hypertrophied detrusor preparations usually lacked such spontaneous activity. 4. In calcium-free saline, agonist induced responses of both normal and hypertrophied detrusor muscle were dramatically reduced indicating that choline ester activity in the muscles was strongly de pendent upon extracellular calcium. 5. Nifedipine at 10(-5) mol l(-1) inhibited acetylcholine responses and K+-induced contractures of both normal and hypertrophied detrusor muscles. Acetylcholine-induced responses of normal detrusor preparations were much more sensitive to inhibition by nifedipine than were the responses of hypertrophied detrusor muscle. 6. The properties and densities of both the muscarinic cholinoreceptors and calcium channels ap pear to have been altered by the hypertrophic response secondary to benign prostatic hyperplasia. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:131 / 136
页数:6
相关论文
共 56 条
[1]  
ANDERSSON KE, 1986, ACTA PHARMACOL TOX, V58, P193
[2]   CURRENT CONCEPTS IN THE TREATMENT OF DISORDERS OF MICTURITION [J].
ANDERSSON, KE .
DRUGS, 1988, 35 (04) :477-494
[3]   SYMPATHETIC ACTIVITY IN PROXIMAL URETHRA IN PATIENTS WITH URINARY OBSTRUCTION [J].
AWAD, SA ;
DOWNIE, JW ;
LYWOOD, DW ;
YOUNG, RA ;
JARZYLO, SV .
JOURNAL OF UROLOGY, 1976, 115 (05) :545-547
[4]   DISTRIBUTION OF ALPHA-ADRENOCEPTORS AND BETA-ADRENOCEPTORS IN HUMAN URINARY-BLADDER [J].
AWAD, SA ;
BRUCE, AW ;
CARROCIA.G ;
DOWNIE, JW ;
LIN, M ;
MARKS, GS .
BRITISH JOURNAL OF PHARMACOLOGY, 1974, 50 (04) :525-529
[5]  
BALYEAT RM, 1930, JAMA-J AM MED ASSOC, V98, P1545
[6]   CYSTOMETRIC RESPONSE TO PROPANTHELINE IN DETRUSOR HYPERREFLEXIA - THERAPEUTIC IMPLICATIONS [J].
BLAIVAS, JG ;
LABIB, KB ;
MICHALIK, SJ ;
ZAYED, AAH .
JOURNAL OF UROLOGY, 1980, 124 (02) :259-262
[7]   MECHANISMS OF ACTION OF TRANSMITTERS AND OTHER SUBSTANCES ON SMOOTH-MUSCLE [J].
BOLTON, TB .
PHYSIOLOGICAL REVIEWS, 1979, 59 (03) :606-718
[8]   EMEPRONIUM BROMIDE (CETIPRIN) - ITS EFFECT ON BLADDER PRESSURE AND URINARY FLOW IN HEALTHY SUBJECTS [J].
BOMAN, J ;
VONGARRE.B .
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 1973, 7 (2-3) :153-157
[9]  
BRADLEY DV, 1970, J CLIN PHARMACOL N D, V10, P65
[10]   CLINICAL TRIAL OF EMEPRONIUM BROMIDE IN NOCTURNAL FREQUENCY OF OLD AGE [J].
BROCKLEHURST, JC ;
DILLANE, JB ;
FRY, J ;
ARMITAGE, P .
BMJ-BRITISH MEDICAL JOURNAL, 1969, 2 (5651) :216-+