Immunological properties of dehydroepiandrosterone, its conjugates, and metabolites

被引：15

作者：

Bradlow, HL ^{[1
]}

Murphy, J ^{[1
]}

Byrne, JJ ^{[1
]}

机构：

[1] AMUR Pharmaceut Co, San Carlos, CA 94070 USA

来源：

NEUROENDOCRINE IMMUNE BASIS OF THE RHEUMATIC DISEASES | 1999年 / 876卷

关键词：

D O I：

10.1111/j.1749-6632.1999.tb07627.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The immunological response to the administration of various C-19 steroids has been of increasing interest. Although the action of dehydroepiandrosterone has been studied, the responses to its metabolites have not been explored. In the present study the ability of dehydroepiandrosterone, its conjugates, and metabolites to oppose the anti-inflammatory action of glucocorticoids on the inflammatory response to 2,4-dinitrochlorobenzene in the sensitized mouse was examined. A clear difference was seen between the antiglucocorticoid activity of dehydroepiandrosterone, its conjugates, and its 5 beta-metabolites on the one hand and the planar 5 alpha- and Delta 4-metabolites, which were devoid of antiglucocorticoid activity. The mechanism of this antiglucocorticoid activity remains to be established.

引用

页码：91 / 101

页数：11

共 21 条

[1] IMMUNOCHEMICAL STUDY ON THE CONTRIBUTION OF HYPOLIPIDEMIC-INDUCED CYTOCHROME-P-452 TO THE METABOLISM OF LAURIC ACID AND ARACHIDONIC-ACID [J].