Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse?

被引：256

作者：

Meaney, MJ ^{[1
]}

Brake, W ^{[1
]}

Gratton, A ^{[1
]}

机构：

[1] McGill Univ, Douglas Hosp, Res Ctr, McGill Ctr Study Behav Genes & Environm, Montreal, PQ H4H 1R3, Canada

来源：

PSYCHONEUROENDOCRINOLOGY | 2002年 / 27卷 / 1-2期

关键词：

maternal separation; dopamine; dopamine transporter; cocaine; stress;

D O I：

10.1016/S0306-4530(01)00040-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Repeated periods of maternal separation in the early life of rats decreased dopamine transporter expression and significantly increased dopamine responses to stress, and behavioral responses to either stress or cocaine. As adults, maternal separation animals showed increased sensitivity to the effects of cocaine on locomotor activity and greater sensitivity to stress-induced sensitization to the effects of amphetamine on locomotor activity. These findings raise the possibility that in addition to effects on stress reactivity, early life events might dispose individuals to illness in later life through effects on very specific neuro transmitter systems. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：127 / 138

页数：12

共 41 条

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