Chemical constituents of Calophyllum brasiliensis:: Structure elucidation of seven new xanthones and their cancer chemopreventive activity

被引：78

作者：

Ito, C

Itoigawa, M ^{[2
]}

Mishina, Y

Cechinel, V

Mukainaka, T

Tokuda, H

Nishino, H

Furukawa, H

机构：

[1] Meijo Univ, Fac Pharm, Nagoya, Aichi 4688503, Japan

[2] Tokai Gakuen Univ, Aichi 4700207, Japan

[3] UNIVALI, CCS, NIQFAR, BR-88302202 Itajai, SC, Brazil

[4] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyou Ku, Kyoto 6020841, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 03期

关键词：

D O I：

10.1021/np010398s

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The first study of chemical constituents of the stem bark of Calophyllum brasilienses collected in Brazil has led to the isolation and identification of seven new xanthones named brasixanthones A (1), B (4), C (5), D (6), E (2), F (3), and G (10), together with 10 known xanthones. Among the xanthones isolated in this study, 4, 5, 6, and 11 were found to exhibit significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.

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页码：267 / 272

页数：6

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