Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes

被引：300

作者：

Gong, Tao ^{[1
,2
,3
,4
]}

Yang, Yanqing ^{[5
]}

Jin, Tengchuan ^{[1
,2
,3
]}

Jiang, Wei ^{[1
,2
,3
,7
]}

Zhou, Rongbin ^{[1
,2
,3
,6
,7
]}

机构：

[1] Univ Sci & Technol China, Inst Immunol, Sch Life Sci, CAS Ctr Excellence Mol Cell Sci, Hefei 230027, Anhui, Peoples R China

[2] Univ Sci & Technol China, CAS Key Lab Innate Immun & Chron Dis, Sch Life Sci, CAS Ctr Excellence Mol Cell Sci, Hefei 230027, Anhui, Peoples R China

[3] Univ Sci & Technol China, Med Ctr, Hefei 230027, Anhui, Peoples R China

[4] Bengbu Med Coll, Dept Immunol, Anhui Prov Key Lab Infect & Immun, Bengbu 233030, Anhui, Peoples R China

[5] Bengbu Med Coll, Dept Clin Lab, Affiliated Hosp 1, Bengbu 233030, Anhui, Peoples R China

[6] Univ Sci & Technol China, Innovat Ctr Cell Signaling Network, Hefei 230027, Anhui, Peoples R China

[7] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China

来源：

TRENDS IN IMMUNOLOGY | 2018年 / 39卷 / 05期

基金：

中国国家自然科学基金;

关键词：

NALP3; INFLAMMASOME; K+ EFFLUX; CALCIUM; CA2+; MITOCHONDRIA; MEMBRANE; PYROPTOSIS; PORE; RECEPTOR; INTERLEUKIN-1-BETA;

D O I：

10.1016/j.it.2018.01.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The assembly of the NLRP3 inflammasome can promote the release of IL-1 beta/IL-18 and initiate pyroptosis. Accordingly, the dysregulation of NLRP3 inflammasome activation is involved in a variety of human diseases, including gout, diabetes, and Alzheimer's disease. NLRP3 can sense a variety of structurally unrelated pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) to trigger inflammation, but the unifying mechanism of NLRP3 activation is still poorly understood. Increasing evidence suggests that intracellular ions, such as K+, Ca2+, and Cl-, have a significant role in NLRP3 inflammasome activation. Here, we review the current knowledge about the role of ionic fluxes in NLRP3 inflammasome activation and discuss how disturbances in intracellular ionic levels orchestrate different signaling events upstream of NLRP3.

引用

页码：393 / 406

页数：14

共 84 条

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Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome [J].