In vitro activity of doripenem against Acinetobacter baumannii clinical isolates

被引：24

作者：

Marti, Sara ^{[1
]}

Sanchez-Cespedes, Javier ^{[1
]}

Alba, Veronica ^{[1
]}

Vila, Jordi ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin Barcelona, Fac Med, Ctr Diagnost Biomed,Serv Microbiol, E-08036 Barcelona, Spain

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2009年 / 33卷 / 02期

关键词：

Acinetobacter baumannii; Carbapenems; Doripenem; RESISTANCE;

D O I：

10.1016/j.ijantimicag.2008.08.015

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Doripenem is a carbapenem with activity against Gram-positive and Gram-negative pathogens. This study evaluated the in vitro activity of doripenem against a collection of 87 Acinetobacter baumannii clinical isolates, showing that the activity of doripenem was superior to imipenem and meropenem for strains carrying the bla(OXA-58) gene. A. baumannii clinical isolates expressing the bla(OXA-24) gene were resistant to doripenem, imipenem and meropenem. However, in clinical isolates expressing the bla(OXA-58) gene, the percentage of isolates with a doripenem minimum inhibitory concentration >8 mu g/mL was much lower than that of imipenem and meropenem. This study shows that the activity of doripenem was superior to imipenem and meropenem for strains carrying the bla(OXA-58) gene. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：181 / 182

页数：2

共 11 条

[1]

[Anonymous], M100S17 CLSI

[2]

Antimicrobial activity of doripenem (S-4661): a global surveillance report (2003) [J].