Dynamics of skeletal muscle lipid pools

被引：69

作者：

Badin, Pierre-Marie ^{[1
,2
]}

Langin, Dominique ^{[1
,2
,3
]}

Moro, Cedric ^{[1
,2
]}

机构：

[1] Fac Med Toulouse, INSERM, Obes Res Lab, Inst Metab & Cardiovasc Dis I2MC,Unite Mixte Rech, F-31073 Toulouse, France

[2] Univ Toulouse 3, UMR1048, F-31062 Toulouse, France

[3] Toulouse Univ Hosp, Dept Clin Biochem, Toulouse, France

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2013年 / 24卷 / 12期

关键词：

intramyocellular lipids; lipolysis; exercise; fat oxidation; insulin sensitivity; type; 2; diabetes; ATGL; HORMONE-SENSITIVE LIPASE; ADIPOSE TRIGLYCERIDE LIPASE; PROTEIN-KINASE-C; HEPATIC INSULIN SENSITIVITY; FREE FATTY-ACID; PERILIPIN; TRIACYLGLYCEROL HYDROLYSIS; CERAMIDE CONTENT; KNOCKOUT MICE; RESISTANCE;

D O I：

10.1016/j.tem.2013.08.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Intramyocellular triacylglycerol (IMTG) is emerging as an important energy fuel source during muscle contraction and are adaptively increased in response to exercise, without adverse physiological effects. Paradoxically, elevated IMTG content in obese and type 2 diabetics has been linked to insulin resistance, highlighting the importance of IMTG pools in physiology and pathology. Two separate views suggest that IMTG dynamics are determinant for skeletal muscle fat oxidation, and that disruption of IMTG dynamics facilitates the accumulation of lipotoxic intermediates such as diacylglycerols and ceramides that interfere with insulin signaling. Thus, understanding the factors that control IMTG dynamics is crucial. Here we discuss recent literature describing the regulation of IMTG pools with a particular emphasis on lipases and lipid droplet (LD)-associated proteins.

引用

收藏

页码：607 / 615

页数：9

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