C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome

被引：127

作者：

Choi, Kyung Mook ^{[1
]}

Hwang, Soon Young ^{[2
]}

Hong, Ho Cheol ^{[1
]}

Yang, Sae Jeong ^{[1
]}

Choi, Hae Yoon ^{[1
]}

Yoo, Hye Jin ^{[1
]}

Lee, Kwan Woo ^{[3
]}

Nam, Moon Suk ^{[4
]}

Park, Yong Soo ^{[5
]}

Woo, Jeong Taek ^{[6
]}

Kim, Young Seol ^{[6
]}

Choi, Dong Seop ^{[1
]}

Youn, Byung-Soo ^{[7
]}

Baik, Sei Hyun ^{[1
]}

机构：

[1] Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul 136705, South Korea

[2] Korea Univ, Coll Med, Dept Biostat, Seoul 136705, South Korea

[3] Ajou Univ, Coll Med, Dept Internal Med, Suwon 441749, South Korea

[4] Inha Univ, Coll Med, Dept Internal Med, Inchon, South Korea

[5] Hanyang Univ, Coll Med, Dept Internal Med, Seoul 133791, South Korea

[6] Kyung Hee Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[7] AdipoGen Inc, Inchon, South Korea

来源：

DIABETES | 2012年 / 61卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

INSULIN-RESISTANCE; COLLAGENOUS REPEAT; ADIPOKINE; GENE; CTRP3/CARTDUCIN; PROLIFERATION; SEQUENCE; LEVEL; FAT;

D O I：

10.2337/db12-0217

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, highsensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors. Diabetes 61:2932-2936, 2012

引用

页码：2932 / 2936

页数：5

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