CI Solvent Yellow 14 shows activity in the bone marrow micronucleus assay in both the rat and mouse

被引：9

作者：

Elliott, BM ^{[1
]}

Griffiths, K ^{[1
]}

Mackay, JM ^{[1
]}

Wade, JD ^{[1
]}

机构：

[1] ZENECA SPECIALTIES,MANCHESTER,LANCS,ENGLAND

来源：

MUTAGENESIS | 1997年 / 12卷 / 04期

关键词：

D O I：

10.1093/mutage/12.4.255

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

CI Solvent Yellow 14 has been reported to be carcinogenic in the rat, inducing neoplastic liver nodules, but noncarcinogenic in the mouse, The present experiments have extended previously reported investigations on the activity of CI Solvent Yellow 14 in in vivo genotoxicity assays, CI Solvent Yellow 14 has been examined for genotoxicity in vivo in the bone marrow micronucleus assay in both the rat and the mouse, and in the rat liver unscheduled DNA synthesis (DNA repair) assay, to limit doses of 5000 and 2000 mg/kg respectively, by oral gavage, CI Solvent Yellow 14 showed evidence of clastogenic activity in both the rat and mouse bone marrow (clear effect in the rat; weak effect in the mouse), but no evidence of DNA repair in the rat liver, In view of the latter finding, the contribution, if any, of the genotoxicity expressed by the micronucleus assay to the formation of liver nodules on chronic administration of the compound, is unclear.

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页码：255 / 258

页数：4

相关论文

共 10 条

[1] AN ASSESSMENT OF THE INVIVO RAT HEPATOCYTE DNA-REPAIR ASSAY [J].

ASHBY, J ;

LEFEVRE, PA ;

BURLINSON, B ;

PENMAN, MG .

MUTATION RESEARCH, 1985, 156 (1-2) :1-18

[2] MUTAGENIC ACTIVITY OF 27 DYES AND RELATED CHEMICALS IN THE SALMONELLA MICROSOME AND MOUSE LYMPHOMA TK+/- ASSAYS [J].

CAMERON, TP ;

HUGHES, TJ ;

KIRBY, PE ;

FUNG, VA ;

DUNKEL, VC .

MUTATION RESEARCH, 1987, 189 (03) :223-261

[3] CHROMOSOMAL-ABERRATIONS AND SISTER CHROMATID EXCHANGE TESTS IN CHINESE-HAMSTER OVARY CELLS-INVITRO .4. RESULTS WITH 15 CHEMICALS [J].

IVETT, JL ;

BROWN, BM ;

RODGERS, C ;

ANDERSON, BE ;

RESNICK, MA ;

ZEIGER, E .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1989, 14 (03) :165-187

[4] TESTING OF 24 FOOD, DRUG, COSMETIC, AND FABRIC DYES IN THE INVITRO AND THE INVIVO INVITRO RAT HEPATOCYTE PRIMARY CULTURE DNA-REPAIR ASSAYS [J].

KORNBRUST, D ;

BARFKNECHT, T .

ENVIRONMENTAL MUTAGENESIS, 1985, 7 (01) :101-120

[5] MEASUREMENT OF UNSCHEDULED DNA-SYNTHESIS AND S-PHASE SYNTHESIS IN RODENT HEPATOCYTES FOLLOWING INVIVO TREATMENT - TESTING OF 24 COMPOUNDS [J].

MIRSALIS, JC ;

TYSON, CK ;

STEINMETZ, KL ;

LOH, EK ;

HAMILTON, CM ;

BAKKE, JP ;

SPALDING, JW .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1989, 14 (03) :155-164

[6]

*NCI, 1982, US NAT CAN I TECHN R, V226

[7] THE USE OF A SIMPLE HEMATOXYLIN AND EOSIN STAINING PROCEDURE TO DEMONSTRATE MICRONUCLEI WITHIN RODENT BONE-MARROW [J].

PASCOE, S ;

GATEHOUSE, D .

MUTATION RESEARCH, 1986, 164 (04) :237-243

[8] INACTIVITY OF METHYLENE-CHLORIDE IN THE MOUSE BONE-MARROW MICRONUCLEUS ASSAY [J].

SHELDON, T ;

RICHARDSON, CR ;

ELLIOTT, BM .

MUTAGENESIS, 1987, 2 (01) :57-59

[9] THE DIFFERENTIAL CLASTOGENICITY OF SOLVENT YELLOW 14 AND FD AND C-YELLOW-6 INVIVO IN THE RODENT MICRONUCLEUS TEST (OBSERVATIONS ON SPECIES AND TISSUE-SPECIFICITY) [J].

WESTMORELAND, C ;

GATEHOUSE, DG .

CARCINOGENESIS, 1991, 12 (08) :1403-1407

[10] SALMONELLA MUTAGENICITY TESTS .4. RESULTS FROM THE TESTING OF 300 CHEMICALS [J].

ZEIGER, E ;

ANDERSON, B ;

HAWORTH, S ;

LAWLOR, T ;

MORTELMANS, K .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1988, 11 :1-158