Microvortex for focusing, guiding and sorting of particles

被引：109

作者：

Hsu, Chia-Hsien ^{[1
,2
]}

Di Carlo, Dino ^{[1
,2
]}

Chen, Chihchen ^{[1
,2
]}

Irimia, Daniel ^{[1
,2
]}

Toner, Mehmet ^{[1
,2
,3
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Engn Med & Surg Serv, BioMEMS Resource Ctr, Shriners Hosp Children, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Boston, MA 02129 USA

来源：

LAB ON A CHIP | 2008年 / 8卷 / 12期

关键词：

D O I：

10.1039/b813434k

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report a microvortex manipulator (MVM) that is a passive, scalable system with great potential for the manipulation and separation of particulate samples in microfluidic environments. The movement of particles is determined by a unique combination of helical flow, buoyant, and gravitational forces. Helical flows are induced by topographically patterned microchannel surfaces, which have previously been used for molecular mixing in microfluidic devices. We illustrate the mechanism of MVM and its applications in passive focusing of beads and cells into parallel streams and guiding of particles and cells. We also explore the application of the unique density-selectivity of microvortex focusing and successfully sort a mixture of two bead populations whose density difference is as small as 0.1 g cm(-3).

引用

页码：2128 / 2134

页数：7

共 37 条

[1] Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping [J].