Ligand profiling and identification technology for searching bioactive ligands

被引:1
作者
Baek, MC
Kim, SJ
Yea, K
Kim, Y
Lee, BD
Kim, J
Lee, HJ
Kang, MH
Choi, SK
Kim, JI
Lee, TG
Suh, PG
Ryu, SH
机构
[1] Pohang Univ Sci & Technol, Div Mol & Life Sci, Pohang 790784, South Korea
[2] Kyungpook Natl Univ, Sch Med, Dept Mol Med, Taegu, South Korea
[3] Pohang Univ Sci & Technol, Peptide Lib Support Facil, Postech Biotech Ctr, Pohang 790784, South Korea
[4] Sigmol Inc, Pohang, South Korea
关键词
identification; ligand; peptidome; profiling;
D O I
10.1002/pmic.200500511
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We introduce a new methodology named ligand profiling and identification for effective discovery of bioactive ligands such as peptide hormones. This technology was developed from a new concept of parallel column chromatography and active fraction profiling by nano-LC MS. Traditional methods use sequential column chromatography, and thus are inevitably limited by the low abundance of the peptide of interest and by a low yield due to the many column steps. Using this new technology, insulin was successfully identified and diarginylinsulin, a minor intermediate form of insulin, was unexpectedly also identified simultaneously from 100 mg of porcine pancreatic tissue. This integrative technology could be used to search for various low-abundance peptides (or bioactive molecules) rapidly and simultaneously, by applying this to the later stages of traditional sequential purification.
引用
收藏
页码:1741 / 1749
页数:9
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