Three new cryptophycins from Nostoc sp. GSV 224

被引：69

作者：

Subbaraju, GV ^{[1
]}

Golakoti, T ^{[1
]}

Patterson, GML ^{[1
]}

Moore, RE ^{[1
]}

机构：

[1] UNIV HAWAII,DEPT CHEM,HONOLULU,HI 96822

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 03期

关键词：

D O I：

10.1021/np960700a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cryptophycin 46 (2), -175 (3), and -176 (4) have been identified as three new trace constituents of Nostoc sp. GSV 224. Cryptophycin-46 is an epimer of cryptophycin-3 (5) and to date is the only naturally occurring analogue having the S configuration at C-10 (C-2 in Unit B). Cryptophycins-175 and -176 also differ in unit B where 3 is the O-methyl analogue of cryptophycin-45 (6) and 4 is the O-desmethyl analogue of cryptophycin-21 (8). The relative and absolute stereochemistries of the three new analogues have been related to known cryptophycins by synthesis.

引用

页码：302 / 305

页数：4

共 4 条

[1] TOTAL SYNTHESIS OF CRYPTOPHYCINS - REVISION OF THE STRUCTURES OF CRYPTOPHYCIN-A AND CRYPTOPHYCIN-C [J].