A new method for the formation of the imidazo[4',5';3,4]pyrido[2,3-b]indole ring: Formal synthesis of the alkaloids from marine origin grossularines -1 and 2.

被引：19

作者：

Molina, P

Fresneda, PM

Sanz, MA

机构：

[1] Depto. de Quim. Orgánica, Universidad de Murcia, Campus de Espinardo, E-30071, Murcia

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(97)01592-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of the 2-dimethylamino-4-hydroxy-6-methoxymethyl-3H-imidazo[4', 5':3,4] pyrido[2,3-b]indole,used as key intermediate in the total synthesis of the alkaloids grossularines -1 and -2, based on the step-wise formation of the pyridine and imidazole rings, is described. (C) 1997 Elsevier Science Ltd.

引用

页码：6909 / 6912

页数：4

共 20 条

[1] A SHORT ENTRY INTO THE PYRIDO[2,3-B]INDOLE RING-SYSTEM - SYNTHESIS OF THE TETRACYCLIC SEGMENT OF THE MARINE ANTITUMOR AGENTS - GROSSULARINE-1 AND GROSSULARINE-2
ACHAB, S
GUYOT, M
POTIER, P
[J]. TETRAHEDRON LETTERS, 1993, 34 (13) : 2127 - 2130
[2] ACHAB S, 1995, TETRAHEDRON LETT, P2615
[3] ALBIZATI KF, 1992, SYNTHESIS MARINE NAT, V6, P158
[4] 2-AMINOIMIDAZOLES AND THEIR ZINC-COMPLEXES FROM INDO-PACIFIC LEUCETTA SPONGES AND NOTODORIS NUDIBRANCHS
ALVI, KA
PETERS, BM
HUNTER, LM
CREWS, P
[J]. TETRAHEDRON, 1993, 49 (02) : 329 - 336
[5] NEW LEUKOTRIENE-B4 RECEPTOR ANTAGONIST - LEUCETTAMINE-A AND RELATED IMIDAZOLE ALKALOIDS FROM THE MARINE SPONGE LEUCETTA-MICRORAPHIS
CHAN, GW
MONG, S
HEMLING, ME
FREYER, AJ
OFFEN, PH
DEBROSSE, CW
SARAU, HM
WESTLEY, JW
[J]. JOURNAL OF NATURAL PRODUCTS, 1993, 56 (01): : 116 - 121
[6] CHOSHI T, 1995, SYNLETT, P147
[7] TOTAL SYNTHESIS OF GROSSULARINES-1 AND-2
CHOSHI, T
YAMADA, S
SUGINO, E
KUWADA, T
HIBINO, S
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (18) : 5899 - 5904
[8] COMMERCON A, 1991, TETRAHEDRON LETT, V32, P1416
[9] MARINE NATURAL-PRODUCTS
FAULKNER, DJ
[J]. NATURAL PRODUCT REPORTS, 1992, 9 (04) : 323 - 364
[10] A NEW IMIDAZOLE ALKALOID FROM THE MARINE SPONGE LEUCETTA-MICRORHAPHIS
HE, HY
FAULKNER, DJ
LEE, AY
CLARDY, J
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (07) : 2176 - 2178

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