Steroids from Dysoxylum grande (Meliaceae) leaves

被引：17

作者：

Wah, Low Kok ^{[1
]}

Abas, Faridah ^{[2
,3
]}

Cordell, Geoffrey A. ^{[4
]}

Ito, Hideyuki ^{[5
]}

Ismail, Intan Safinar ^{[1
,2
]}

机构：

[1] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor, Malaysia

[2] Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang 43400, Selangor, Malaysia

[3] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang 43400, Selangor, Malaysia

[4] Nat Prod Inc, Evanston, IL 60203 USA

[5] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008530, Japan

来源：

STEROIDS | 2013年 / 78卷 / 02期

关键词：

Dysoxylum grande; Grandol derivatives; Secodammarenoic acid derivative; Anti-acetylcholinesterase; LENTICELLARE; TRITERPENES; STEM;

D O I：

10.1016/j.steroids.2012.09.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Seven new 23-oxo-cholestane derivatives named as grandol A (1), B (2), C (3), D (4), E (5), F (6), and G (7) were isolated from Dysoxylum grande leaves alongside with a new 3,4-secodammar-4(28)-en-3-oic acid derivative (8). The structures of the compounds were elucidated based on the interpretation of spectroscopic data, and their relative configurations were established by NOESY 2D NMR data. All of the isolates were tested for anti-acetylcholinesterase activity using thin layer chromatography (TLC)-bioautography with fast blue B salt. Only grandol A (1) and B (2) showed positive results, with clear discoloration at a concentration of 12.5 ppm. However, the obtained IC50 values for grandol A and B, when using Ellman's method, were not significant (>200 mu g/ml). (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：210 / 219

页数：10

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