Mitochondrial medicine - recent advances

被引：46

作者：

Graff, C

Clayton, DA

Larsson, NG

机构：

[1] Karolinska Hosp, Ctr Mol Med, Dept Mol Med, S-17176 Stockholm, Sweden

[2] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

JOURNAL OF INTERNAL MEDICINE | 1999年 / 246卷 / 01期

关键词：

ageing; diabetes mellitus; genetics; mitochondrial diseases; neurodegenerative diseases; radical oxygen species;

D O I：

10.1046/j.1365-2796.1999.00514.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitochondria contain the respiratory chain enzyme complexes that carry out oxidative phosphorylation and produce the main part of cellular energy in the form of ATP. Mitochondrial DNA (mtDNA) encodes essential subunits of the respiratory chain and is thus critical for maintaining cellular energy production. The first pathogenic mtDNA mutations were reported in 1988, and today more than 50 disease-causing mtDNA mutations have been identified. In addition, mtDNA mutations have been implicated in ageing and in common disorders such as diabetes mellitus, heart failure and Parkinson's disease, This review will summarize recent advances in the rapidly expanding field of mitochondrial medicine.

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页码：11 / 23

页数：13

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