Differentiation of embryonic stem cells is induced by GATA factors

被引：414

作者：

Fujikura, J

Yamato, E

Yonemura, S

Hosoda, K

Masui, S

Nakao, K

Miyazaki, J

Niwa, H

机构：

[1] Osaka Univ, Grad Sch Med, Area Mol Therapeut,Course Adv Med, Suita, Osaka 5650871, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Kyoto 6068507, Japan

[3] Kyoto Univ, Fac Med, Lab Cellular Morphogenesis Res, RIKEN Ctr Dev Biol, Kyoto 6068501, Japan

[4] Kyoto Univ, Fac Med, Dept Cell Biol, Kyoto 6068501, Japan

[5] RIKEN, Ctr Dev Biol, Lab Pluripotent Cell Studies, Kobe, Hyogo 6500047, Japan

来源：

GENES & DEVELOPMENT | 2002年 / 16卷 / 07期

关键词：

Gata-6; Gata-4; transcription factor; extraembryonic endoderm; embryonic stem cells;

D O I：

10.1101/gad.968802

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Extraembryonic endoderm (ExE) is differentiated from the inner cell mass of the late blastocyst-stage embryo to form visceral and parietal endoderm, both of which have an important role in early embryogenesis. The essential roles of Gata-6 and Gata-4 on differentiation of visceral endoderm have been identified by analyses of knockout mice. Here we report that forced expression of either Gata-6 or Gata-4 in embryonic stem (ES) cells is sufficient to induce the proper differentiation program towards ExE. We believe that this is the first report of a physiological differentiation event induced by the ectopic expression of a transcription factor in ES cells.

引用

页码：784 / 789

页数：6

共 37 条

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Endoderm-specific gene expression in embryonic stem cells differentiated to embryoid bodies [J].