Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity

被引：71

作者：

Berman, FW

Gerwick, WH

Murray, TF

机构：

[1] Univ Georgia, Coll Vet Med, Dept Physiol & Pharmacol, Athens, GA 30601 USA

[2] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA

来源：

TOXICON | 1999年 / 37卷 / 11期

关键词：

D O I：

10.1016/S0041-0101(99)00108-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Curacin-A, antillatoxin and kalkitoxin, natural products from the marine cyanobacterium Lyngbya majuscula, were tested for neurotoxicity in primary cultures of rat cerebellar granule neurons. Curacin-A was non-toxic, whereas antillatoxin and kalkitoxin produced concentration-dependent cytotoxicity with LC50 values of 20.1 +/- 6.4 and 3.86 +/- 1.91 nM, respectively. Antillatoxin neurotoxicity was produced acutely, whereas kalkitoxin caused a delayed neurotoxic response. The cytotoxicity produced by both antillatoxin and kalkitoxin was prevented by the non-competitive NMDA receptor antagonists dextrorphan and MK-801. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1645 / 1648

页数：4

共 10 条

[1]

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[2]

2-N

[3]

Berman F W, 1996, J Biochem Toxicol, V11, P217, DOI 10.1002/(SICI)1522-7146(1996)11:5<217::AID-JBT2>3.3.CO

[4]

2-B