BLAST 2 SEQUENCES, a new tool for comparing protein and nucleotide sequences

被引：194

作者：

Tatusova, TA ^{[1
]}

Madden, TL ^{[1
]}

机构：

[1] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA

来源：

FEMS MICROBIOLOGY LETTERS | 1999年 / 174卷 / 02期

关键词：

algorithm; sequence alignment; software;

D O I：

10.1111/j.1574-6968.1999.tb13575.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

'BLAST 2 SEQUENCES', a new BLAST-based tool for aligning two protein or nucleotide sequences, is described. While the standard BLAST program is widely used to search for homologous sequences in nucleotide and protein databases, one often needs to compare only two sequences that are already known to be homologous, coming from related species or, e.g. different isolates of the same virus. In such cases searching the entire database would be unnecessarily time-consuming. 'BLAST 2 SEQUENCES' utilizes the BLAST algorithm for pairwise DNA-DNA or protein-protein sequence comparison. A World Wide Web version of the program can be used interactively at the NCBI WWW site (http://www.ncbi.nlm.nih.gov/gorf/bl2.html). The resulting alignments are presented in both graphical and text form. The variants of the program for PC (Windows), Mac and several UNIX-based platforms can be downloaded from the NCBI FTP site (ftp://ncbi.nlm.nih.gov). (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：247 / 250

页数：4

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