Tissue adhesive using synthetic model adhesive proteins inspired by the marine mussel

被引：18

作者：

Tatehata, H

Mochizuki, A

Ohkawa, K

Yamada, M

Yamamoto, H ^{[1
]}

机构：

[1] Shinshu Univ, Fac Text Sci & Technol, Inst High Polymer Res, Ueda, Nagano 3868567, Japan

[2] Terumo Co Ltd, Ctr Res & Dev, Kanagawa 2590151, Japan

来源：

JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY | 2001年 / 15卷 / 09期

关键词：

marine adhesive protein; synthetic polypeptides; wettability; tissue compatibility; pigskin; surface free energy;

D O I：

10.1163/156856101317035459

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

\The surface free energy and its dispersion and polar components of pigskin were determined by wettability measurements. The contact angles and work of adhesion of solutions of the synthetic model adhesive sequence poly(Gly-Tyr-Lys) inspired by marine adhesive proteins were measured on the epidermis and the dermis of pigskin. Also the surface free energy of pigskin was determined using contact angles of certain probe liquids. When a poly(Gly-Tyr-Lys) buffer solution containing tyrosinase as a bioadhesion formulation was used to close an incision of a living pig, a good incision adhesion and reduced immunological response after 1 week were observed from photographs using an optical microscope and the amount of macrophages by image analysis.

引用

页码：1003 / 1013

页数：11

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