Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation

被引:45
作者
Barchet, W
Price, JD
Cella, M
Colonna, M
MacMillan, SK
Cobb, JP
Thompson, PA
Murphy, KM
Atkinson, JP
Kemper, C
机构
[1] Washington Univ, Sch Med, Div Rheumatol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pathol & Immunol,Div Biostat, Grad Program Immunol,Dept Surg, St Louis, MO 63110 USA
关键词
D O I
10.1182/blood-2005-07-2951
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Concurrent activation of the T-cell receptor (TCR) and complement regulator CD46 on human CD4(+) T lymphocytes induces Tr1-like regulatory T cells that suppress through IL-10 secretion bystander T-cell proliferation. Here we show that, despite their IL-10 production, CD46-induced T-regulatory T cells (Tregs) do not suppress the activation/maturation of dendritic cells (DCs). DC maturation by complement/ CD46-induced Tregs is mediated through simultaneous secretion of GM-CSF and soluble CD40L, factors favoring DC differentiation and reversing inhibitory effects of IL-10. Thus, CD46-induced Tregs produce a distinct cytokine profile that inhibits T-cell responses but leaves DC activation unimpaired. Such '' DC-sparing '' Tregs could be desirable at host/environment interfaces such as the gastrointestinal tract where their specific cytokine profile provides a mechanism that ensures unresponsiveness to commensal bacteria while maintaining reactivity to invading pathogens. (Blood. 2006; 107:1497-1504) (c) 2006 by The American Society of Hematology.
引用
收藏
页码:1497 / 1504
页数:8
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