Sequence-Controlled Multi-Block Glycopolymers to Inhibit DC-SIGN-gp120 Binding

被引：204

作者：

Zhang, Qiang ^{[1
]}

Collins, Jennifer ^{[1
]}

Anastasaki, Athina ^{[1
]}

Wallis, Russell ^{[2
]}

Mitchell, Daniel A. ^{[3
]}

Becer, C. Remzi ^{[1
]}

Haddleton, David M. ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Leicester, Dept Biochem, Leicester LE1 9HN, Leics, England

[3] Univ Warwick, Warwick Med Sch, Clin Sci Res Inst, Coventry CV2 2DX, W Midlands, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 16期

关键词：

block copolymers; glycosylation; polymerization; polymers; supramolecular chemistry; LIVING RADICAL POLYMERIZATION; DC-SIGN; CLICK CHEMISTRY; LIGAND-BINDING; HIV ENTRY; SET-LRP; LECTIN; GLYCOPROTEIN; RECOGNITION; POLYMERS;

D O I：

10.1002/anie.201300068

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chain of command: Multi-block glycopolymers made of mannose (M, see figure), glucose, and di(ethylene glycol) ethyl ether (D) monomers were synthesized using a technique to control the polymer sequence. These highly monodisperse glycopolymers were then tested for binding and inhibition of DC-SIGN, a protein important for HIV infection. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4435 / 4439

页数：5

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