共 21 条
The transmembrane domain directs TLR9 to intracellular compartments that contain TLR3
被引:32
作者:

Kajita, E
论文数: 0 引用数: 0
h-index: 0
机构:
Hokkaido Univ, Grad Sch Med, Dept Cellular Pharmacol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ, Grad Sch Med, Dept Cellular Pharmacol, Sapporo, Hokkaido 0608638, Japan

Nishiya, T
论文数: 0 引用数: 0
h-index: 0
机构:
Hokkaido Univ, Grad Sch Med, Dept Cellular Pharmacol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ, Grad Sch Med, Dept Cellular Pharmacol, Sapporo, Hokkaido 0608638, Japan

Miwa, S
论文数: 0 引用数: 0
h-index: 0
机构:
Hokkaido Univ, Grad Sch Med, Dept Cellular Pharmacol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ, Grad Sch Med, Dept Cellular Pharmacol, Sapporo, Hokkaido 0608638, Japan
机构:
[1] Hokkaido Univ, Grad Sch Med, Dept Cellular Pharmacol, Sapporo, Hokkaido 0608638, Japan
关键词:
intracellular localization;
toll-like receptor 9;
transmembrane domain;
D O I:
10.1016/j.bbrc.2006.03.014
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Toll-like receptors (TLRs) are type I transmembrane (TM) proteins indispensable for sensing microbial and viral infection. Despite their conserved primary structures, some TLRs that detect pathogen-derived nucleic acids (TLR3, TLR7, TLR8, and TLR9) are retained in the cytoplasm. The intracellular localization of TLR9 is important for its ability to discriminate self- and non-scif DNA, but the mechanism by which it is retained in the cytoplasm is unclear. In the present study, we found that the TM domain of TLR9 directs its intracellular localization. The TM domain of TLR9 also targets CD25, a heterologous type I TM protein, to intracellular compartments that contain TLR9. We also found that TLR9 generally co-localizes with TLR3, although its linker region, not its TM domain, directs intracellular localization of TLR3. These data demonstrate that the TM domain of TLR9 is a critical regulatory element that targets TLR9 to its intracellular location. (c) 2006 Elsevier Inc. All rights reserved.
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页码:578 / 584
页数:7
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