Management of acute severe ulcerative colitis (NICE CG 166)

被引：15

作者：

Macken, Lucia ^{[1
]}

Blaker, Paul A. ^{[1
]}

机构：

[1] Tunbridge Wells Hosp Pembury, Gastroenterol, Pembury TN2 4QJ, England

来源：

CLINICAL MEDICINE | 2015年 / 15卷 / 05期

关键词：

Ulcerative colitis; severe; ciclosporin; infliximab; colectomy; INFLAMMATORY-BOWEL-DISEASE; INTRAVENOUS CYCLOSPORINE; COLECTOMY; CORTICOSTEROIDS;

D O I：

10.7861/clinmedicine.15-5-473

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Ulcerative colitis (UC) presents as an acute severe flare in 10-15% of new cases and it occurs in 15% of patients with established disease. Acute severe UC can lead to significant morbidity and mortality in predominantly younger patients without other comorbidities. Inpatient hospital admission and a multidisciplinary approach are vital in appropriate and timely management. Important but simple aspects in the initial work-up and treatment of such patients are frequently overlooked during the acute medical take. An overview of the general and more specialist management of this important presentation are discussed herein.

引用

页码：473 / 476

页数：4

共 17 条

[1]

Ciclosporin use in acute ulcerative colitis: a long-term experience [J].

Campbell, S ;

Travis, S ;

Jewell, D .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2005, 17 (01) :79-84

[2]

Cohen RD, 1999, INFLAMM BOWEL DIS, V5, P1

[3]

Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis [J].

D'Haens, G ;

Lemmens, L ;

Geboes, K ;

Vandeputte, L ;

Van Acker, F ;

Mortelmans, L ;

Peeters, M ;

Vermeire, S ;

Penninckx, F ;

Nevens, F ;

Hiele, M ;

Rutgeerts, P .

GASTROENTEROLOGY, 2001, 120 (06) :1323-1329

[4]

Doherty Glen A, 2009, Expert Rev Gastroenterol Hepatol, V3, P395, DOI 10.1586/egh.09.24

[5]

An Accelerated Infliximab Induction Regimen Reduces the Need for Early Colectomy in Patients With Acute Severe Ulcerative Colitis [J].

Gibson, David J. ;

Heetun, Zaid S. ;

Redmond, Ciaran E. ;

Nanda, Kavin S. ;

Keegan, Denise ;

Byrne, Kathryn ;

Mulcahy, Hugh E. ;

Cullen, Garret ;

Doherty, Glen A. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2015, 13 (02) :330-U170

[6]

CYCLOSPORINE IN SEVERE ULCERATIVE-COLITIS REFRACTORY TO STEROID-THERAPY [J].

LICHTIGER, S ;

PRESENT, DH ;

KORNBLUTH, A ;

GELERNT, I ;

BAUER, J ;

GALLER, G ;

MICHELASSI, F ;

HANAUER, S .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (26) :1841-1845

[7]

A prospective randomized controlled trial of intravenous ciprofloxacin as an adjunct to corticosteroids in acute, severe ulcerative colitis [J].

Mantzaris, GJ ;

Petraki, K ;

Archavlis, E ;

Amberiadis, P ;

Kourtessas, D ;

Christidou, A ;

Triantafyllou, G .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2001, 36 (09) :971-974

[8]

The role of colonoscopy in the differential diagnosis of acute, severe hemorrhagic colitis [J].

Mantzaris, GJ ;

Hatzis, A ;

Archavlis, E ;

Petraki, K ;

Lazou, A ;

Ladas, S ;

Triantafyllou, G ;

Raptis, SA .

ENDOSCOPY, 1995, 27 (09) :645-653

[9]

PREVALENCE OF INFLAMMATORY BOWEL-DISEASE AMONG RELATIVES OF PATIENTS WITH ULCERATIVE-COLITIS [J].

MONSEN, U ;

BROSTROM, O ;

NORDENVALL, B ;

SORSTAD, J ;

HELLERS, G .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1987, 22 (02) :214-218

[10]

Incidence of colectomy during long-term follow-up after cyclosporine-induced remission of severe ulcerative colitis [J].

Moskovitz, David N. ;

Van Assche, Gert ;

Maenhout, Benedikte ;

Arts, Joris ;

Ferrante, Marc ;

Vermeire, Severine ;

Rutgeerts, Paul .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2006, 4 (06) :760-765

← 1 2 →