Structural investigation of cisplatin-protein interactions: Selective platination of His19 in a cuprozinc superoxide dismutase

被引：100

作者：

Calderone, V

Casini, A

Mangani, S ^{[1
]}

Messori, L

Orioli, PL

机构：

[1] Univ Siena, Dept Chem, I-53100 Siena, Italy

[2] Univ Florence, Dept Chem, I-50019 Florence, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 08期

关键词：

antitumor agents; cisplatin; platinum; superoxide dismutase; X-ray diffraction;

D O I：

10.1002/anie.200502599

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drug adduct: The X-ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8-Å resolution. Selective platination of His19 occurs far away from the copper-zinc site. Remarkably, the protein-bound platinum center retains both chloro ligands (see picture, Cu orange, Zn dark gray, Pt light gray, Cl green). (Figure Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：1267 / 1269

页数：3

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