The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

被引：7

作者：

Chung, WK

Luke, A

Cooper, RS

Rotini, C

Vidal-Puig, A

Rosenbaum, M

Gordon, D

Leal, SM

Caprio, S

Goldsmith, R

Andreu, AL

Bruno, C

DiMauro, S

Heo, M

Lowe, WL

Lowell, BB

Allison, DB

Leibel, RL

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Dept Med, Div Mol Genet,Naomi Berrie Diabet Ctr, New York, NY 10032 USA

[3] Loyola Univ, Med Ctr, Dept Epidemiol & Prevent Med, Maywood, IL 60153 USA

[4] Rockefeller Univ, New York, NY 10021 USA

[5] Beth Israel Deaconess Med Ctr, Div Endocrinol, Boston, MA 02215 USA

[6] Yale Univ, Sch Med, Div Pediat Endocrinol, New Haven, CT 06510 USA

[7] Columbia Univ, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Obes Res Ctr, New York, NY 10025 USA

[8] Northwestern Univ, Sch Med, Dept Med, Chicago, IL 60611 USA

[9] Columbia Univ Coll Phys & Surg, H Houston Merritt Clin Res Ctr Muscular Dystrophy, New York, NY 10032 USA

来源：

INTERNATIONAL JOURNAL OF OBESITY | 1999年 / 23卷 / Suppl 6期

关键词：

obesity; diabetes; skeletal muscle; thermogenesis;

D O I：

10.1038/sj.ijo.0800945

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3> have been described in humans, but not in rodents. The functional consequences-or lack thereof-of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

引用

页码：S49 / S50

页数：2

共 14 条

[1] Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes [J].