Decreased Levels of Circulating IL-21 in HIV-Infected AIDS Patients: Correlation with CD4+ T-Cell Counts

被引：63

作者：

Iannello, Alexandre ^{[1
,3
]}

Tremblay, Cecile ^{[2
,3
]}

Routy, Jean-Pierre ^{[4
]}

Boulassel, Mohamed-Rachid ^{[4
]}

Toma, Emil ^{[2
,3
]}

Ahmad, Ali ^{[1
,3
]}

机构：

[1] Ste Justine Hosp, Res Ctr, Lab Innate Immun, Montreal, PQ, Canada

[2] Univ Montreal, Hosp Hotel Dieu, Montreal, PQ, Canada

[3] Univ Montreal, Dept Microbiol & Immunol, Montreal, PQ H3C 3J7, Canada

[4] McGill Univ, Dept Haematol, Montreal, PQ, Canada

来源：

VIRAL IMMUNOLOGY | 2008年 / 21卷 / 03期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1089/vim.2008.0025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

IL-21 is a relatively newly discovered multifunctional and pleiotropic cytokine. It is produced primarily by CD4(+) T cells, the principal targets of the virus, and therefore this cytokine has special relevance to HIV infection. Here we show for the first time that serum levels of this cytokine are significantly reduced in HIV-infected AIDS patients and correlate significantly with their CD4(+) T-cell counts. These data suggest that the cytokine levels could act as a valuable biomarker for the progression of AIDS.

引用

页码：385 / 388

页数：4

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