Synthesis of sulfamide linked dinucleotide analogues

被引：8

作者：

Micklefield, J

Fettes, KJ

机构：

[1] Department of Chemistry, Birkbeck College, University of London, London WC1H 0PP, Gordon House

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 30期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(97)01179-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel sulfamide [-NHSO2NH-] linked dinucleotide analogues d(TnsnT) and d(TnsnA) have been synthesised from 3'- and 5'-amino nucleosides. Treatment of these amino nucleosides with catechol sulfate results in the formation of 2-hydroxyphenyl sulfamate eaters which couple smoothly in good yields with either 5'- or 3'-amines of similar nucleosides. NMR studies showed that the 3'-sulfamide group results in a preferential C3'-endo (Northern) sugar conformation. (C) 1997 Elsevier Science Ltd.

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收藏

页码：5387 / 5390

页数：4

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