DENdb: database of integrated human enhancers

被引：37

作者：

Ashoor, Haitham ^{[1
]}

Kleftogiannis, Dimitrios ^{[2
]}

Radovanovic, Aleksandar ^{[1
]}

Bajic, Vladimir B. ^{[1
]}

机构：

[1] KAUST, CBRC, Comp Elect & Math Sci & Engn Div CEMSE, Thuwal 239556900, Saudi Arabia

[2] KAUST, Comp Elect & Math Sci & Engn Div CEMSE, Thuwal 239556900, Saudi Arabia

来源：

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2015年

关键词：

WEB SERVER; TRANSCRIPTION; ELEMENTS; DISCOVERY;

D O I：

10.1093/database/bav085

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Enhancers are cis-acting DNA regulatory regions that play a key role in distal control of transcriptional activities. Identification of enhancers, coupled with a comprehensive functional analysis of their properties, could improve our understanding of complex gene transcription mechanisms and gene regulation processes in general. We developed DENdb, a centralized on-line repository of predicted enhancers derived from multiple human cell-lines. DENdb integrates enhancers predicted by five different methods generating an enriched catalogue of putative enhancers for each of the analysed cell-lines. DENdb provides information about the overlap of enhancers with DNase I hypersensitive regions, ChIP-seq regions of a number of transcription factors and transcription factor binding motifs, means to explore enhancer interactions with DNA using several chromatin interaction assays and enhancer neighbouring genes. DENdb is designed as a relational database that facilitates fast and efficient searching, browsing and visualization of information.

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