Survivin - biology and potential as a therapeutic target in oncology

被引：127

作者：

Cheung, Chun Hei Antonio

Huang, Chien-Chang ^{[3
]}

Tsai, Fang-Ying ^{[4
]}

Lee, Jane Ying-Chieh ^{[1
]}

Cheng, Siao Muk ^{[2
]}

Chang, Yung-Chieh ^{[1
]}

Huang, Yi-Chun ^{[1
]}

Chen, Shang-Hung ^{[5
]}

Chang, Jang-Yang ^{[3
,6
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70101, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 70101, Taiwan

[3] Natl Hlth Res Inst, Natl Inst Canc Res, Tainan 70456, Taiwan

[4] Natl Cheng Kung Univ, Coll Med, SEAHECT, Tainan 70101, Taiwan

[5] Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol, Tainan, Taiwan

[6] Natl Cheng Kung Univ Hosp, Dept Internal Med, Div Hematol & Oncol, Tainan 70428, Taiwan

来源：

ONCOTARGETS AND THERAPY | 2013年 / 6卷

关键词：

survivin; BIRC5; IAP; XIAP; caspase-9; Samc; DIABLO; NUCLEAR EXPORT; AURORA-B; ANTIAPOPTOSIS GENE; PROTEIN SURVIVIN; CELL-DIVISION; CANCER CELLS; EXPRESSION; PHOSPHORYLATION; APOPTOSIS; SENSITIVITY;

D O I：

10.2147/OTT.S33374

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression has been widely demonstrated to occur in various types of cancer. Overexpression of survivin also correlates with tumor progression and induces anticancer drug resistance. Interestingly, recent studies reveal that survivin exhibits multiple pro-mitotic and anti-apoptotic functions; the differential functions of survivin seem to be caused by differential subcellular localization, phosphorylation, and acetylation of this molecule. In this review, the complex expression regulations and post-translational modifications of survivin are discussed. This review also discusses how recent discoveries improve our understanding of survivin biology and also create opportunities for developing differential-functioned survivin-targeted therapy. Databases such as PubMed, Scopus (R) (Elsevier, New York, NY, USA), and SciFinder (R) (CAS, Columbus, OH, USA) were used to search for literature in the preparation of this review.

引用

页码：1453 / 1462

页数：10

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