A short synthesis of the potent antitumor agent (±)-hydroxymethylacylfulvene using an allenic Pauson-Khand type cycloaddition

被引:77
作者
Brummond, KM [1 ]
Lu, JL [1 ]
机构
[1] W Virginia Univ, Dept Chem, Morgantown, WV 26506 USA
关键词
D O I
10.1021/ja990426h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:5087 / 5088
页数:2
相关论文
共 18 条
  • [1] An intramolecular allenic [2+2+1]cycloaddition
    Brummond, KM
    Wan, HH
    Kent, JL
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (19) : 6535 - 6545
  • [2] The allenic Pauson-Khand cycloaddition.: Dependence in π-bond selectivity on substrate structure.
    Brummond, KM
    Wan, H
    [J]. TETRAHEDRON LETTERS, 1998, 39 (09) : 931 - 934
  • [3] STUDIES ON SESQUITERPENOIDS OF HYPOLEPIS-PUNCTATA-METT .2. TOTAL SYNTHESIS OF HYPACRONE
    HAYASHI, Y
    NISHIZAWA, M
    SAKAN, T
    [J]. TETRAHEDRON, 1977, 33 (19) : 2513 - 2519
  • [4] Efficacy of MGI 114 (6-hydroxymethylacylfulvene, HIMAF) against the mdr1/gp170 Metastatic MV522 lung carcinoma xenograft
    Kelner, MJ
    McMorris, TC
    Estes, L
    Samson, KM
    Bagnell, RD
    Taetle, R
    [J]. EUROPEAN JOURNAL OF CANCER, 1998, 34 (06) : 908 - 913
  • [5] Kelner MJ, 1996, INVEST NEW DRUG, V14, P161
  • [6] A NEW ALLENIC PAUSON-KHAND CYCLOADDITION FOR THE PREPARATION OF ALPHA-METHYLENE CYCLOPENTENONES
    KENT, JL
    WAN, HH
    BRUMMOND, KM
    [J]. TETRAHEDRON LETTERS, 1995, 36 (14) : 2407 - 2410
  • [7] TOTAL SYNTHESIS OF (+/-)-ILLUDIN-M
    KINDER, FR
    BAIR, KW
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (23) : 6965 - 6967
  • [8] MacDonald JR, 1997, CANCER RES, V57, P279
  • [9] TOTAL SYNTHESIS OF DL-ILLUDIN M
    MATSUMOTO, T
    SHIRAHAMA, H
    ICHIHARA, A
    SHIN, H
    KAGAWA, S
    SAKAN, F
    MATSUMOTO, S
    NISHIDA, S
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1968, 90 (12) : 3280 - +
  • [10] Reaction of antitumor hydroxymethylacylfulvene (HMAF) with thiols
    McMorris, TC
    Yu, J
    Estes, LA
    Kelner, MJ
    [J]. TETRAHEDRON, 1997, 53 (43) : 14579 - 14590