On the turnover of brain cholesterol in patients with Alzheimer's disease.: Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

被引：158

作者：

Bogdanovica, N

Bretillon, L

Lund, EG

Diczfalusy, U

Lannfelt, L

Winblad, B

Russell, DW

Björkhem, I

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Clin Chem, SE-14186 Huddinge, Sweden

[2] Huddinge Univ Hosp, Karolinska Inst, Div Geriatr Med, S-14186 Huddinge, Sweden

[3] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75235 USA

来源：

NEUROSCIENCE LETTERS | 2001年 / 314卷 / 1-2期

关键词：

cerebral cholesterol; cholesterol; 24S-hydroxylase; cytochrome P-450; oxysterols; Alzheimer's disease;

D O I：

10.1016/S0304-3940(01)02277-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Evidence is accumulating for a link between cerebral cholesterol metabolism and Alzheimer's disease (AD). Here we focus on a possible relationship between AD and a newly discovered mechanism for cholesterol eff lux from the brain, involving conversion of brain cholesterol into 24S-hydroxycholesterol by the neuronal oxidative enzyme CYP46. There was a marked difference in the distribution of CYP46 in brains of control and AD patients. The neuronal cells were less stained in AD brains than in controls while marked positive staining was found in glial cells in AD but not in controls. The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid P-protein in AD. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：45 / 48

页数：4

共 16 条

[1]

Avdulov NA, 1997, J NEUROCHEM, V69, P1746

[2]

Björkhem I, 1998, J LIPID RES, V39, P1594

[3] Importance of a novel oxidative mechanism for elimination of brain cholesterol - Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with O-18(2) techniques in vivo and in vitro [J].