Early identification of atopy in the prediction of persistent asthma in children

被引：292

作者：

Sly, Peter D. ^{[1
]}

Boner, Attilio L. ^{[2
]}

Bjorksten, Bengt ^{[3
]}

Bush, Andy ^{[4
]}

Custovic, Adnan ^{[5
]}

Eigenmann, Philippe A. ^{[6
]}

Gern, James E. ^{[7
]}

Gerritsen, Jorrit ^{[8
]}

Hamelmann, Eckard ^{[9
]}

Helms, Peter J. ^{[10
]}

Lemanske, Robert F. ^{[7
]}

Martinez, Fernando ^{[11
]}

Pedersen, Soren ^{[12
]}

Renz, Harald ^{[13
,14
]}

Sampson, Hugh ^{[15
]}

von Mutius, Erika ^{[16
]}

Wahn, Ulrich ^{[9
]}

Holt, Patrick G. ^{[1
]}

机构：

[1] Univ Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, Perth, WA 6009, Australia

[2] Univ Verona, I-37100 Verona, Italy

[3] Karolinska Inst, Natl Inst Environm Med, Stockholm, Sweden

[4] Royal Brompton Hosp, London SW3 6LY, England

[5] Univ Manchester, Wythenshawe Hosp, Manchester, Lancs, England

[6] Univ Childrens Hosp Geneva, Geneva, Switzerland

[7] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA

[8] Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands

[9] Charite, D-13353 Berlin, Germany

[10] Univ Aberdeen, Royal Aberdeen Childrens Hosp, Aberdeen, Scotland

[11] Arizona Resp Ctr, Tucson, AZ USA

[12] Univ So Denmark, Kolding Hosp, Kolding, Denmark

[13] Univ Hosp Giessen, Marburg, Germany

[14] Marburg GmbH, Marburg, Germany

[15] Mt Sinai Sch Med, Dept Pediat, New York, NY USA

[16] Univ Munich, Childrens Hosp, D-8000 Munich, Germany

来源：

LANCET | 2008年 / 372卷 / 9643期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0140-6736(08)61451-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The long-term solution to the asthma epidemic is thought to be prevention, and not treatment of established disease. Atopic asthma arises from gene-environment interactions, which mainly take place during a short period in prenatal and postnatal development. These interactions are not completely understood, and hence primary prevention remains an elusive goal. We argue that primary-care physicians, paediatricians, and specialists lack knowledge of the role of atopy in early life in the development of persistent asthma in children. In this review, we discuss how early identification of children at high risk is feasible on the basis of available technology and important for potential benefits to the children. Identification of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, and sets the basis for future preventative strategies.

引用

页码：1100 / 1106

页数：7

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