The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages

被引：186

作者：

Saleque, S

Cameron, S

Orkin, SH ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Dana Farber Canc Inst,Dept Pediat Oncol, Boston, MA 02115 USA

[2] Howard Hughes Med Inst, Boston, MA 02115 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

[4] Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

GENES & DEVELOPMENT | 2002年 / 16卷 / 03期

关键词：

transcription factor; hematopoiesis; development; oncogene;

D O I：

10.1101/gad.959102

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gfi-1 and Gfi-1b are novel proto-oncogenes identified by retroviral insertional mutagenesis. By gene targeting, we establish that Gfi-1b is required for the development of two related blood lineages, erythroid and megakaryocytic, in mice. Gfi-1b(-/-) embryonic stem cells fail to contribute to red cells of adult chimeras. Gfi-1b(-/-) embryos exhibit delayed maturation of primitive erythrocytes and subsequently die with failure to produce definitive enucleated erythrocytes. The fetal liver of mutant mice contains erythroid and megakaryocytic precursors arrested in their development. Myelopoiesis is normal. Therefore, Gfi-1b is an essential transcriptional regulator of erythroid and megakaryocyte development.

引用

收藏

页码：301 / 306

页数：6

相关论文

共 34 条

[1] u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila [J].

Cubadda, Y ;

Heitzler, P ;

Ray, RP ;

Bourouis, M ;

Ramain, P ;

Gelbart, W ;

Simpson, P ;

Haenlin, M .

GENES & DEVELOPMENT, 1997, 11 (22) :3083-3095

[2] The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila [J].

Fossett, N ;

Tevosian, SG ;

Gajewski, K ;

Zhang, Q ;

Orkin, SH ;

Schulz, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (13) :7342-7347

[3] Structure and erythroid cell-restricted expression of a chicken cDNA encoding a novel zinc finger protein of the Cys+His class [J].

Fuchs, B ;

Wagner, T ;

Rossel, N ;

Antoine, M ;

Beug, H ;

Niessing, J .

GENE, 1997, 195 (02) :277-284

[4] A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis [J].

Gao, YJ ;

Sun, Y ;

Frank, KM ;

Dikkes, P ;

Fujiwara, Y ;

Seidl, KJ ;

Sekiguchi, JM ;

Rathbun, GA ;

Swat, W ;

Wang, JY ;

Bronson, RT ;

Malynn, BA ;

Bryans, M ;

Zhu, CM ;

Chaudhuri, J ;

Davidson, L ;

Ferrini, R ;

Stamato, T ;

Orkin, SH ;

Greenberg, ME ;

Alt, FW .

CELL, 1998, 95 (07) :891-902

[5] PROGRESSION OF INTERLEUKIN-2 (IL-2)-DEPENDENT RAT T-CELL LYMPHOMA LINES TO IL-2-INDEPENDENT GROWTH FOLLOWING ACTIVATION OF A GENE (GFI-1) ENCODING A NOVEL ZINC FINGER PROTEIN [J].

GILKS, CB ;

BEAR, SE ;

GRIMES, HL ;

TSICHLIS, PN .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1759-1768

[6]

Gilliland DG, 1998, LEUKEMIA, V12, pS7

[7] The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death [J].

Grimes, HL ;

Gilks, CB ;

Chan, TO ;

Porter, S ;

Tsichlis, PN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) :14569-14573

[8]

Grimes HL, 1996, MOL CELL BIOL, V16, P6263

[9] Transcriptional activity of Pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila [J].

Haenlin, M ;

Cubadda, Y ;

Blondeau, F ;

Heitzler, P ;

Lutz, Y ;

Simpson, P ;

Ramain, P .

GENES & DEVELOPMENT, 1997, 11 (22) :3096-3108

[10]

Jia YW, 1997, DEVELOPMENT, V124, P2063

← 1 2 3 4 →