Antiinflammatory activity of adrenomedullin in the acetic acid peritonitis in rats

被引：30

作者：

Clementi, G ^{[1
]}

Caruso, A ^{[1
]}

Cutuli, VMC ^{[1
]}

Prato, A ^{[1
]}

Mangano, NG ^{[1
]}

Amico-Roxas, M ^{[1
]}

机构：

[1] Univ Catania, Sch Med, Inst Pharmacol, I-95125 Catania, Italy

来源：

LIFE SCIENCES | 1999年 / 65卷 / 15期

关键词：

adrenomedullin; CGRP; inflammation;

D O I：

10.1016/S0024-3205(99)00406-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The antiinflammatory effect of ADM was studied in different models of inflammation and compared to the one of CGRP. Peptides were active against acetic acid-induced peritonitis in the rats. ADM and CGRP exerted the antiinflammatory effect at different doses, 400 and 20 ng/kg respectively, but with different efficacy (ADM >CGRP). This effect was blocked by pretreatment with CGRP (8-37) fragment or with L-NAME. No antiinflammatory activity was evidenced against serotonin - or carrageenin - induced rat paw edema. Our data suggest that ADM exerts antiinflammatory activity in the model characterized by a vascular component. This effect involves CGRP receptors and appears to be mediated by nitric oxide system. (C) 1999 Elsevier Science Inc.

引用

页码：PL203 / PL208

页数：6

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