Laryngeal aspergillosis following high dose inhaled fluticasone therapy for asthma

被引：34

作者：

Fairfax, AJ

David, V

Douce, G

机构：

[1] Stafford Gen Hosp, Dept Resp Med, Stafford ST16 3SA, England

[2] Stafford Gen Hosp, Dept Ear Nose & Throat Surg, Stafford ST16 3SA, England

[3] Stafford Gen Hosp, Dept Pathol, Stafford ST16 3SA, England

来源：

THORAX | 1999年 / 54卷 / 09期

关键词：

laryngeal aspergillosis; Aspergillus fumigatus; asthma; fluticasone propionate;

D O I：

10.1136/thx.54.9.860

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The case history is presented of a 75 year old man with chronic asthma who was treated with inhaled fluticasone propionate in a daily dose of 2 mg using a Diskhaler. After three years of treatment he developed progressive hoarseness. Both vocal cords were colonised by Aspergillus fumigatus which formed a white slough on the surface. Biopsy specimens showed changes suggestive of laryngeal aspergillosis with an ulcerated epithelium, fibrinopurulent debris, and colonies of fungal hyphae. A slow recovery occurred after three months of treatment with topical amphotericin and with cessation of inhaled corticosteroids. Laryngoscopy is recommended if hoarseness occurs during treatment with fluticasone.

引用

页码：860 / 861

页数：2

共 8 条

[1]

AYRES JG, 1995, EUR RESPIR J, V8, P579

[2] ASPERGILLOSIS OF THE LARYNX [J].