Determining the conformation of thiolated poly(ethylene glycol) on Au nanoshells by surface-enhanced Raman scattering spectroscopic assay

被引：85

作者：

Levin, Carly S.

Bishnoi, Sandra Whaley

Grady, Nathaniel K.

Halas, Naomi J.

机构：

[1] Rice Univ, Dept Chem, Dept Elect & Comp Engn, Houston, TX 77005 USA

[2] Rice Univ, Lab Nanophoton, Houston, TX 77005 USA

[3] IIT, Dept Biol Chem & Phys Sci, Chicago, IL 60616 USA

来源：

ANALYTICAL CHEMISTRY | 2006年 / 78卷 / 10期

关键词：

D O I：

10.1021/ac060041z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The packing density of thiolated poly(ethylene glycol) (PEG) adsorbates on Au nanoshells is determined by exploiting the surface-enhanced Raman scattering response of individual nanoshell substrates. By incorporating the linker molecule p-mercaptoaniline (pMA), the number of 2000 MW and 5000 MW PEG molecules on each nanoparticle is determined by interpolation of the Langmuir isotherm for pMA. We conclude that both PEG adsorbates maintain a compact "brush" rather than an extended "mushroom" configuration on nanoshell surfaces.

引用

页码：3277 / 3281

页数：5

共 34 条

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