A mild and highly selective N-benzoylation of cytosine and adenine bases in nucleosides with N-benzoyltetrazole

被引：26

作者：

Bhat, B

Sanghvi, YS

机构：

[1] ISIS Pharmaceuticals, Medicinal Chemistry Department, Carlsbad, CA 92008

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(97)10423-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Benzoyltetrazole has been developed as a mild and selective reagent for monobenzoylation of the exocyclic amino group in nucleic acid bases. its usefulness is demonstrated by protection of adenine and cytosine bases, an important procedure in the nucleic acid chemistry field. (C) 1997 Elsevier Science Ltd.

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页码：8811 / 8814

页数：4

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