Differences in lung bioavailability between different propellants for fluticasone propionate

被引:18
作者
Wilson, AM [1 ]
Sims, EJ [1 ]
Orr, LC [1 ]
Lipworth, BJ [1 ]
机构
[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Clin Pharmacol & Therapeut, Asthma & Allergy Res Grp, Dundee DD1 9SY, Scotland
关键词
D O I
10.1016/S0140-6736(99)03581-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The lung bioavailability las adrenal suppression) of fluticasone propionate was about two-fold greater with chlorofluorocarbons than hydrofluoroalkane as propellant. Direct switching between formulations on a mu g equivalent may therefore be inadvisable.
引用
收藏
页码:1357 / 1358
页数:2
相关论文
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CRIPPS AL, 1997, J AEROSOL MED, V10
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