A moenomycin-type structural analogue of lipid II some possible mechanisms of the mode of action of transglycosylase inhibitors can be discarded

被引：15

作者：

Kosmol, R

Hennig, L

Welzel, P

Findeisen, M

Muller, D

Markus, A

vanHeijenoort, J

机构：

[1] UNIV LEIPZIG,INST ORGAN CHEM,D-04103 LEIPZIG,GERMANY

[2] UNIV LEIPZIG,INST ANALYT CHEM,D-04103 LEIPZIG,GERMANY

[3] RUHR UNIV BOCHUM,FAK CHEM & MINERAL,D-4630 BOCHUM,GERMANY

[4] HOECHST AG,D-6230 FRANKFURT,GERMANY

[5] UNIV PARIS 11,ORSAY,FRANCE

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1997年 / 339卷 / 04期

关键词：

D O I：

10.1002/prac.19973390162

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

The transglycosylation step in the peptidoglycan biosynthesis belongs to the general class of glycosyltransferase-catalyzed reactions. The structural analogue 2 of moenomycin A has been synthesized and has been found to be antibiotically inactive. The assumption that moenomycin-type transglycosylase inhibitors such as 1 bind at the donor site of the enzyme and that their mode of action is the result of the high stability of the sugar --> phosphate bond seems to be ruled out by the present results.

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页码：340 / 358

页数：19

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