Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease

被引：214

作者：

Merched, A

Xia, Y

Visvikis, S

Serot, JM

Siest, G ^{[1
]}

机构：

[1] Univ Henri Poincare Nancy 1, Ctr Med Prevent, F-54500 Vandoeuvre Nancy, France

[2] Unite INSERM 523, F-54500 Vandoeuvre Nancy, France

[3] Hop Hotel Dieu, F-54350 Mont St Martin, France

来源：

NEUROBIOLOGY OF AGING | 2000年 / 21卷 / 01期

关键词：

apolipoprotein a-I; Alzheimer's disease; biochemical marker; mini-mental score;

D O I：

10.1016/S0197-4580(99)00103-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Serum apolipoprotein (apo) AI concentration was studied in 98 Alzheimer's disease (AD) patients (77.56 +/- 8.83 years) and 59 healthy, elderly controls (75.37 +/- 5.27 years). ApoAI levels were significantly lower (p < 10(-7)) in AD patients. An apoAI cutoff value of 1.50 g/L, could distinguish between the two groups with a sensitivity of 71% and a specificity of 69%. ApoAI levels were highly correlated with mini-mental state (MMSE) scores of patients (p < 0.0001). These relationships remained significant after adjustment for multiple testing. Our findings raise the question of the potential implication of apoAI in the etiopathology of AD and bring serum apoAI concentration to the fore as an important biochemical marker. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：27 / 30

页数：4

共 20 条

[1] CHARACTERIZATION OF SUBPOPULATIONS OF LIPOPROTEIN PARTICLES ISOLATED FROM HUMAN CEREBROSPINAL-FLUID [J].