Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh

被引：91

作者：

Dolara, P

Corte, B

Ghelardini, C

Pugliese, AM

Cerbai, E

Menichetti, S

Lo Nostro, A

机构：

[1] Univ Florence, Dept Pharmacol, I-50139 Florence, Italy

[2] Univ Florence, Dept Organ Chem, I-50139 Florence, Italy

[3] Univ Florence, Dept Publ Hlth, I-50139 Florence, Italy

来源：

PLANTA MEDICA | 2000年 / 66卷 / 04期

关键词：

D O I：

10.1055/s-2000-8532

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We extracted, purified and characterised 8 sesquiterpene fractions from Commyphora molmol. In particular, we focused our attention on a mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, which showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeroginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 mu g/ml. These compounds also had local anaesthetic activity, blocking the inward sodium current of excitable mammalian membranes.

引用

页码：356 / 358

页数：3

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