Modeling spatial variation in leukemia survival data

被引：80

作者：

Henderson, R ^{[1
]}

Shimakura, S

Gorst, D

机构：

[1] Univ Lancaster, Dept Math & Stat, Lancaster LA1 4YF, England

[2] Univ Fed Parana, Dept Estatist, BR-81531990 Curitiba, Parana, Brazil

[3] Royal Lancaster Infirm, Dept Haematol, Lancaster LA1 4RP, England

来源：

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION | 2002年 / 97卷 / 460期

关键词：

cancer; frailty; geostatistics; hierarchic model; latent process; semiparametric model;

D O I：

10.1198/016214502388618753

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

In this article we combine ideas from spatial statistics with lifetime data analysis techniques to investigate possible spatial variation in survival of adult acute myeloid leukemia patients in northwest England. Exploratory analysis suggests both clinically and statistically significant variation in survival rates across the region. A multivariate gamma frailty model incorporating spatial dependence is proposed and applied, with results confirming the dependence of hazard on location.

引用

页码：965 / 972

页数：8

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