Carcinosarcomas (Malignant Mixed Mullerian Tumor) of the Uterus: Advances in Elucidation of Biologic and Clinical Characteristics

被引：74

作者：

Kernochan, Lauren E. ^{[1
]}

Garcia, Rochelle L. ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2009年 / 7卷 / 05期

关键词：

Malignant mixed Mullerian tumor; carcinosarcoma; uterus; GYNECOLOGIC-ONCOLOGY-GROUP; PHASE-III TRIAL; FEMALE GENITAL-TRACT; UTERINE CARCINOSARCOMAS; ENDOMETRIAL CARCINOMAS; HISTOGENESIS; IFOSFAMIDE; COMPONENTS; OVARIAN; DIFFERENTIATION;

D O I：

10.6004/jnccn.2009.0037

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Carcinosarcoma of the uterus (malignant mixed Mullerian tumor [MMMT]) is an uncommon, typically extremely aggressive neoplasm histologically composed of malignant epithelial and mesenchymal (stromal) elements. Although the literature contains some debate, most authors now agree that most MMMTs derive from sarcomatous differentiation in a high-grade carcinoma. This article reviews the clinical and histopathologic features of this interesting neoplasm, with particular emphasis on recent data supporting MMMTs as primarily epithelial malignant neoplasms with areas of mesenchymal/spindle cell differentiation. (JNCCN 2009;7:550-557)

引用

页码：550 / 556

页数：7

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